Mubarak Muhammed
Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan.
World J Transplant. 2023 Mar 18;13(3):86-95. doi: 10.5500/wjt.v13.i3.86.
Currently, the most feasible and widely practiced option for patients with end-stage organ failure is the transplantation of part of or whole organs, either from deceased or living donors. However, organ shortage has posed and is still posing a big challenge in this field. Newer options being explored are xenografts and engineered/bioengineered tissues/organs. Already small steps have been taken in this direction and sooner or later, these will become a norm in this field. However, these developments will pose different challenges for the diagnosis and management of problems as compared with traditional allografts. The approach to pathologic diagnosis of dysfunction in these settings will likely be significantly different. Thus, there is a need to increase awareness and prepare transplant diagnosticians to meet this future challenge in the field of xenotransplantation/ regenerative medicine. This review will focus on the current status of transplant pathology and how it will be changed in the future with the emerging scenario of routine xenotransplantation.
目前，对于终末期器官衰竭患者，最可行且应用最广泛的选择是移植部分或整个器官，供体可以是已故者或活体。然而，器官短缺在这一领域过去是、现在仍然是一个巨大的挑战。正在探索的新选择是异种移植以及工程化/生物工程化组织/器官。在这个方向上已经迈出了一小步，迟早这些将成为该领域的常态。然而，与传统同种异体移植相比，这些进展将给问题的诊断和管理带来不同的挑战。在这些情况下，功能障碍的病理诊断方法可能会有显著差异。因此，有必要提高认识，并让移植诊断医生做好准备，以应对异种移植/再生医学领域的这一未来挑战。本综述将聚焦于移植病理学的现状，以及随着常规异种移植新情况的出现，其未来将如何变化。
