Penny J E, Kukums J R, Tyrer J H, Eadie M J
J Neurol Sci. 1975 Oct;26(2):187-92. doi: 10.1016/0022-510x(75)90031-3.
Cytophotometric measurements of the activities of 5 enzymes (succinate, malate, and NAD+-linked isocitrate dehydrogenases from the tricarboxylic cycle, lactate dehydrogenase from the Embden-Meyerhof pathway, and NADH dehydrogenase) were correlated with cell volume for neurones in the anterior horn of rabbit lumbar and cervical spinal cord. The data for succinate and isocitrate dehydrogenases indicated that these enzymes were at higher concentrations in the smaller neurones, which consist largely of interneurones. No preferential localization to particular sizes of cell could be assigned to the other enzymes studied. The relationship between enzyme distribution patterns and their possible role in contributing toward susceptibility to ischaemia of particular sizes of neurones is discussed.
对兔腰段和颈段脊髓前角神经元中5种酶（三羧酸循环中的琥珀酸脱氢酶、苹果酸脱氢酶和NAD⁺连接的异柠檬酸脱氢酶、糖酵解途径中的乳酸脱氢酶以及NADH脱氢酶）的活性进行细胞光度测量，并将其与细胞体积相关联。琥珀酸脱氢酶和异柠檬酸脱氢酶的数据表明，这些酶在较小的神经元中浓度较高，这些较小的神经元主要由中间神经元组成。对于所研究的其他酶，无法确定其在特定大小细胞中的优先定位。本文讨论了酶分布模式与它们在特定大小神经元对缺血易感性方面可能发挥的作用之间的关系。
