Zurawski J M, Kelly E A
University of Cincinnati College of Medicine, Department of Obstetrics and Gynecology, OH, USA.
Obstet Gynecol. 1997 Oct;90(4 Pt 2):672-4. doi: 10.1016/s0029-7844(97)00408-0.
Brodifacoum is a potent warfarin-like anticoagulant used in many rat-poisoning products. Its availability has led to several reported human ingestions, none previously reported in pregnancy.
A woman presented at 22 weeks' gestation in hemorrhagic diathesis, attributed to the ingestion of rat poison containing brodifacoum several days earlier. Aggressive vitamin K therapy controlled the maternal coagulopathy, and no fetal hemorrhage was observed by sonography. Her subsequent prenatal course and delivery were unremarkable, and she was delivered of a healthy infant, who has remained well for at least 1 year.
In this patient, brodifacoum ingestion in pregnancy caused substantial maternal hemorrhage, but no fetal hemorrhage or teratogenic effects were observed.
溴敌隆是一种强效的华法林样抗凝剂，用于许多灭鼠产品中。其可得性导致了多起人类摄入的报道，此前尚无孕期摄入的报道。
一名孕22周的女性因数天前摄入含溴敌隆的灭鼠药而出现出血素质。积极的维生素K治疗控制了母体凝血障碍，超声检查未发现胎儿出血。她随后的产前过程和分娩均正常，产下一名健康婴儿，该婴儿至少1年来一直健康。
在该患者中，孕期摄入溴敌隆导致了大量母体出血，但未观察到胎儿出血或致畸作用。
