爱沙尼亚幽门螺杆菌cagA和vacA基因型与胃部疾病的关联
Association of cagA and vacA genotypes of Helicobacter pylori with gastric diseases in Estonia.
作者信息
Andreson Helena, Lõivukene Krista, Sillakivi Toomas, Maaroos Heidi-Ingrid, Ustav Mart, Peetsalu Ants, Mikelsaar Marika
机构信息
Department of Microbiology, University of Tartu, Tartu 50411, Estonia.
出版信息
J Clin Microbiol. 2002 Jan;40(1):298-300. doi: 10.1128/JCM.40.1.298-300.2002.
Abstract
Gastric biopsy specimens from 156 adult patients from southern Estonia suffering from chronic gastritis, peptic ulcer disease, and perforated peptic ulcer were analyzed by PCR. The cagA gene was evenly distributed throughout 87% of the specimens from the patients with the different gastric diseases. The presence of the cagA gene correlated with that of vacA signal sequence type s1a (99%). However, no clear differences were found in the distribution of cagA and vacA genotypes among patients in Estonia with severe perforated peptic ulcer, uncomplicated peptic ulcer, or chronic gastritis.
摘要
对来自爱沙尼亚南部的156名患有慢性胃炎、消化性溃疡病和消化性溃疡穿孔的成年患者的胃活检标本进行了聚合酶链反应（PCR）分析。cagA基因在患有不同胃部疾病患者的87%标本中分布均匀。cagA基因的存在与空泡毒素A（vacA）信号序列类型s1a的存在相关（99%）。然而，在爱沙尼亚患有严重消化性溃疡穿孔、无并发症的消化性溃疡或慢性胃炎的患者中，cagA和vacA基因型的分布没有明显差异。
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