毒力基因与胃十二指肠疾病的关系。
Relationship between virulence genes and gastroduodenal disease.
机构信息
School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Translational Medicine Programs, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
出版信息
J Int Med Res. 2023 Mar;51(3):3000605231161465. doi: 10.1177/03000605231161465.
OBJECTIVE
This study aimed to identify virulence factors and examine their associations with clinical outcomes in Thai patients. Moreover, the association between these genotypes and gastric mucosa morphological patterns was investigated.
METHODS
This retrospective study enrolled patients who underwent esophagogastroduodenoscopy at Suranaree University of Technology Hospital. The presence of the and genes was investigated by real-time polymerase chain reaction.
RESULTS
The -specific genes and were detected in all 698 gastric biopsy specimens. In total, 567 (81.23%) patients with infection were positive for the gene, 443 (63.46%) were positive for the gene, and 370 (53.0%) were positive for both. The genotype was significantly more common in patients with chronic gastritis and peptic ulcers (78.99% and 79.41%, respectively) than the gene (51.48% and 55.88%, respectively) and combined genotypes (32.34% and 47.05%, respectively). Moreover, the genotype was significantly more common in patients with type 4 or 5 gastric mucosa patterns (69.49% and 76.31%, respectively).
CONCLUSIONS
The genotype is the main cause of serious inflammation of the gastric mucosa. The gene is possibly an important factor explaining gastroduodenal disease outcomes in Thai patients with infection.
目的
本研究旨在鉴定泰国患者中与临床结局相关的毒力因子，并探讨这些毒力因子与胃黏膜形态学模式之间的关联。
方法
本回顾性研究纳入了在泰国苏兰拉里理工大学医院接受食管胃十二指肠镜检查的患者。通过实时聚合酶链反应检测 和 基因的存在。
结果
在所有 698 例胃活检标本中均检测到 -特异性基因 和 。共有 567（81.23%）例 感染患者 基因阳性，443（63.46%）例 基因阳性，370（53.0%）例同时阳性。与 基因（分别为 51.48%和 55.88%）和复合基因型（分别为 32.34%和 47.05%）相比， 基因型在慢性胃炎和消化性溃疡患者中更为常见（分别为 78.99%和 79.41%）。此外， 基因型在胃黏膜形态为 4 型或 5 型的患者中更为常见（分别为 69.49%和 76.31%）。
结论
基因型是导致胃黏膜严重炎症的主要原因。 基因可能是解释泰国 感染患者胃十二指肠疾病结局的重要因素。
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