Grosso L, D'Adda A, Bollati C, Gamba S, Zanno C, Bruni B
Ann Osp Maria Vittoria Torino. 1977 Jul-Dec;20(7-12):196-220.
After a review concerning the present knowledge on the hypothalamic peptide releasing hormones, the response of TSH to intravenous administration of TRH in man (Thyreotrophin Releasing Hormone Stimulation Test) is discussed, with regard to clinical endocrinology. Personal investigations with the TRH test were carried out in 3 groups of conditions correlated with thyroid hyperfunction: 1) suspected hyperthyroidism with equivocal routine tests (9 subjects); 2) autonomous thyroid decompensated adenoma, with or without clinical hyperthyroidism (5 subjects); 3) thyrotoxicosis (Graves' disease) in remission phase after pharmacological or surgical treatment (10 subjects). In these conditions the test provided useful diagnostic information for appropriate therapeutical decisions.
在回顾了有关下丘脑肽释放激素的现有知识后，结合临床内分泌学，讨论了人静脉注射促甲状腺激素释放激素（TRH）后促甲状腺激素（TSH）的反应（促甲状腺激素释放激素刺激试验）。在与甲状腺功能亢进相关的3组情况下进行了TRH试验的个人研究：1）常规检查结果不明确的疑似甲状腺功能亢进（9例）；2）自主性甲状腺失代偿性腺瘤，有或无临床甲状腺功能亢进（5例）；3）药物或手术治疗后缓解期的甲状腺毒症（格雷夫斯病）（10例）。在这些情况下，该试验为做出适当的治疗决策提供了有用的诊断信息。
