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致癌霉菌毒素对依赖脱氧核糖核酸的核糖核酸聚合酶和核糖核酸酶H的抑制作用。

Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H.

作者信息

Tashiro F, Hiral K, Ueno Y

出版信息

Appl Environ Microbiol. 1979 Aug;38(2):191-6. doi: 10.1128/aem.38.2.191-196.1979.

DOI:10.1128/aem.38.2.191-196.1979
PMID:117749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC243463/
Abstract

Fourteen mycotoxins were tested for inhibitory effects on ribonucleic acid polymerase of rat liver and Escherichia coli and nuclear ribonuclease H of rat liver and Tetrahymena pyriformis. These enzymes were strongly inhibited by (-)-luteoskyrin, (+)-rugulosin, patulin, and PR toxin.

摘要

检测了14种霉菌毒素对大鼠肝脏和大肠杆菌的核糖核酸聚合酶以及大鼠肝脏和梨形四膜虫的核糖核酸酶H的抑制作用。这些酶受到（-）-藤黄绿菌素、（+）-皱褶青霉素、展青霉素和PR毒素的强烈抑制。

相似文献

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Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H.致癌霉菌毒素对依赖脱氧核糖核酸的核糖核酸聚合酶和核糖核酸酶H的抑制作用。
Appl Environ Microbiol. 1979 Aug;38(2):191-6. doi: 10.1128/aem.38.2.191-196.1979.
2
DNA-attacking ability of carcinogenic mycotoxins in recombination-deficient mutant cells of Bacillus subtilis.致癌霉菌毒素对枯草芽孢杆菌重组缺陷突变细胞的DNA攻击能力
Cancer Res. 1976 Feb;36(2 Pt 1):445-51.
3
A macromolecular inhibitor of rat liver DNA-dependent RNA polymerases.大鼠肝脏DNA依赖性RNA聚合酶的一种大分子抑制剂。
Biochim Biophys Acta. 1977 Feb 3;474(3):467-77. doi: 10.1016/0005-2787(77)90275-1.
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Phaseolinone, a new mycotoxin, inhibits RNA polymerase(s) other than RNA polymerase II.
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Poly(d(A-T)) dependent RNA polymerase activity after treatment of nuclei with micrococcus nuclease.
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Mechanism of the inhibition of transcription by PR toxin, a mycotoxin from Penicillium roqueforti.罗克福青霉产生的霉菌毒素PR毒素抑制转录的机制。
Chem Biol Interact. 1976 Aug;14(3-4):207-16. doi: 10.1016/0009-2797(76)90101-0.
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Inhibition of isolated rat liver RNApolymerases I and II by aminoacridines.氨基吖啶对离体大鼠肝脏RNA聚合酶I和II的抑制作用。
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Inhibitory effects of 3'-modified UTP analogues on DNA-dependent RNA polymerase I and II purified from cherry salmon (Onchorhynchus masou) liver.3'-修饰的UTP类似物对从樱花鲑（Onchorhynchus masou）肝脏中纯化的DNA依赖性RNA聚合酶I和II的抑制作用。
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引用本文的文献

1
Mycotoxins Affecting Animals, Foods, Humans, and Plants: Types, Occurrence, Toxicities, Action Mechanisms, Prevention, and Detoxification Strategies-A Revisit.影响动物、食品、人类和植物的霉菌毒素：类型、存在、毒性、作用机制、预防及解毒策略——再探讨
Foods. 2021 Jun 3;10(6):1279. doi: 10.3390/foods10061279.
2
PR Toxin - Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges.PR毒素——生物合成、遗传调控、毒理学潜力、预防与控制措施：综述与挑战
Front Pharmacol. 2018 Mar 29;9:288. doi: 10.3389/fphar.2018.00288. eCollection 2018.
3
Role of Penicillic Acid in the Phytotoxicity of Penicillium cyclopium and Penicillium canescens to the Germination of Corn Seeds.青霉素酸在青霉属环青霉和青霉属灰绿青霉对玉米种子萌发的毒性中的作用。
Appl Environ Microbiol. 1985 Mar;49(3):660-3. doi: 10.1128/aem.49.3.660-663.1985.
4
Preliminary studies on the carcinogenic effects of Penicillium roqueforti toxin (PR toxin) on rats.罗克福青霉毒素（PR毒素）对大鼠致癌作用的初步研究。
Mycopathologia. 1982 May 22;78(2):125-7. doi: 10.1007/BF00442636.

本文引用的文献

1
Impairments of RNA synthesis in Ehrlich ascites tumour by luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp.
Experientia. 1967 Dec 15;23(12):1001-2. doi: 10.1007/BF02136409.
2
Ribonuclease H. An enzyme degrading the RNA moiety of DNA-RNA hybrids.核糖核酸酶H。一种降解DNA-RNA杂交体中RNA部分的酶。
Eur J Biochem. 1970 Jun;14(2):278-83. doi: 10.1111/j.1432-1033.1970.tb00287.x.
3
Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp.冰岛青霉（Penicillium islandicum Sopp）产生肝毒性色素黄绿青霉素。
Appl Microbiol. 1969 Sep;18(3):406-9. doi: 10.1128/am.18.3.406-409.1969.
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Inhibitory effects of mycotoxins on the protein synthesis in rabbit reticulocytes.
J Biochem. 1969 Sep;66(3):419-22. doi: 10.1093/oxfordjournals.jbchem.a129163.
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Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms.真核生物中DNA依赖性RNA聚合酶的多种形式。
Nature. 1969 Oct 18;224(5216):234-7. doi: 10.1038/224234a0.
6
Toxicological approaches to the metabolites of Fusaria. II. Isolation of fusarenon-X from the culture filtrate of Fusarium nivale Fn 2B.镰刀菌代谢产物的毒理学研究方法。II. 从雪腐镰刀菌Fn 2B培养滤液中分离镰刀菌烯醇-X
Jpn J Exp Med. 1971 Dec;41(6):507-19.
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Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom.
Jpn J Exp Med. 1971 Jun;41(3):177-88.
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Fusareon-X, a toxic principle of Fusarium nivale--culture filtrate.伏雪镰刀菌素-X，雪腐镰刀菌的一种毒性成分——培养滤液。
Experientia. 1969 Oct 15;25(10):1062. doi: 10.1007/BF01901430.
9
A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase.一种大规模纯化大肠杆菌脱氧核糖核酸依赖性核糖核酸聚合酶的新方法。
J Biol Chem. 1969 Nov 25;244(22):6160-7.
10
Inhibition of rat-liver RNA polymerase in vitro by aflatoxin B1 in the presence of microsomal fraction.在微粒体组分存在的情况下，黄曲霉毒素B1对大鼠肝脏RNA聚合酶的体外抑制作用。
Eur J Biochem. 1974 Mar 1;42(2):333-9. doi: 10.1111/j.1432-1033.1974.tb03344.x.