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冰岛青霉(Penicillium islandicum Sopp)产生肝毒性色素黄绿青霉素。

Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp.

作者信息

Ueno Y, Ishikawa I

出版信息

Appl Microbiol. 1969 Sep;18(3):406-9. doi: 10.1128/am.18.3.406-409.1969.

DOI:10.1128/am.18.3.406-409.1969
PMID:5373676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC377994/
Abstract

Various factors affecting the yields of luteoskyrin, a hepatotoxic mycotoxin, and related pigments in the liquid medium were studied. Maximal yields of luteoskyrin (0.13% by isolation) and of other pigments were attained in the late phase of the cultivation. The yield of the pigment was increased by supplying malt extract, malonic acid, glutamic acid, or asparagine. A useful material for preparation of (14)C-labeled luteoskyrin was 2-(14)C-malonate.

摘要

研究了影响肝毒性霉菌毒素黄天精及其相关色素在液体培养基中产量的各种因素。黄天精(分离得到的含量为0.13%)和其他色素的最大产量在培养后期获得。通过添加麦芽提取物、丙二酸、谷氨酸或天冬酰胺可提高色素产量。制备(14)C标记黄天精的有用原料是2-(14)C-丙二酸盐。

相似文献

1
Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp.冰岛青霉(Penicillium islandicum Sopp)产生肝毒性色素黄绿青霉素。
Appl Microbiol. 1969 Sep;18(3):406-9. doi: 10.1128/am.18.3.406-409.1969.
2
Production of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.从冰岛青霉中生产橙黄红菌素并分离出一种新的代谢产物,皮巴斯托醇。
Appl Environ Microbiol. 1978 Mar;35(3):563-6. doi: 10.1128/aem.35.3.563-566.1978.
3
Production of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp.冰岛青霉(Penicillium islandicum Sopp)产生的肝毒性含氯肽
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[Action of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, on oxidative phosphorylation of rat liver mitochondria].
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5
Spin-trapping and direct EPR investigations on the hepatotoxic and hepatocarcinogenic actions of luteoskyrin, an anthraquinoid mycotoxin produced by Penicillium islandicum Sopp. Generations of superoxide anion and luteoskyrin semiquinone radical in the redox systems consisted of luteoskyrin and liver NADPH- or NADH-dependent reductases.对黄绿青霉素(一种由冰岛青霉产生的蒽醌类霉菌毒素)的肝毒性和致癌作用进行自旋捕获和直接电子顺磁共振研究。在由黄绿青霉素和肝脏NADPH或NADH依赖性还原酶组成的氧化还原系统中产生超氧阴离子和黄绿青霉素半醌自由基。
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Inhibitory effects of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, and chemically related pigments on a protozoon, Tetrahymena pyriformis GL.
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Impairments of RNA synthesis in Ehrlich ascites tumour by luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp.
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The binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum sopp, to deoxyribonucleohistone.
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The mode of binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, to deoxyribonucleic acid.
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Appl Environ Microbiol. 1978 Jun;35(6):1074-8. doi: 10.1128/aem.35.6.1074-1078.1978.

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Production of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.从冰岛青霉中生产橙黄红菌素并分离出一种新的代谢产物,皮巴斯托醇。
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本文引用的文献

1
CYTOTOXIC EFFECTS OF THE MYCOTOXINS OF PENICILLIUM ISLANDICUM SOPP, LUTEOSKYRIN AND CHLORINE-CONTAINING PEPTIDE ON CHANG'S LIVER CELLS AND HELA CELLS.
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[THE EFFECTS OF LUTEOSKYRIN, TOXIC SUBSTANCE FROM PENICILLIUM ISLANDICUM SOPP, ON THE SWELLING OF MITOCHONDRIA].[冰岛青霉产生的有毒物质黄绿青霉素对线粒体肿胀的影响]
Jpn J Exp Med. 1964 Aug;34:197-209.
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MITOCHONDRIAL RESPIRATORY IMPAIRMENT BY LUTEOSKYRIN, A HEPATOTOXIC PIGMENT OF PENICILLIUM ISLANDICUM SOPP.冰岛青霉的肝毒性色素黄绿青霉素对线粒体呼吸的损害
Jpn J Exp Med. 1964 Jun;34:135-52.
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Metabolic products of fungi. X. The structure of rubroskyrin and its relation to the structure of luteoskyrin.
Pharm Bull. 1956 Aug;4(4):309-13. doi: 10.1248/cpb1953.4.309.
5
Impairments of RNA synthesis in Ehrlich ascites tumour by luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp.
Experientia. 1967 Dec 15;23(12):1001-2. doi: 10.1007/BF02136409.
6
[Interactions between pigments and nucleic acids. 4. Specific and non specific complexes between luteoskyrine, magnesium ions, and nucleic acids].
Eur J Biochem. 1967 Apr;1(2):147-51. doi: 10.1111/j.1432-1033.1967.tb00056.x.
7
The binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum sopp, to deoxyribonucleohistone.
J Biochem. 1968 Mar;63(3):395-7.
8
Inhibitory effects of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, and chemically related pigments on a protozoon, Tetrahymena pyriformis GL.
Jpn J Exp Med. 1968 Jun;38(3):157-64.
9
The mode of binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, to deoxyribonucleic acid.
Jpn J Exp Med. 1968 Feb;38(1):47-64.