罗克福青霉毒素（PR毒素）对大鼠致癌作用的初步研究。
Preliminary studies on the carcinogenic effects of Penicillium roqueforti toxin (PR toxin) on rats.
作者信息
Polonelli L, Lauriola L, Morace G
出版信息
Mycopathologia. 1982 May 22;78(2):125-7. doi: 10.1007/BF00442636.
PMID:7099243
Abstract
Preliminary results on the carcinogenic activity of a mycotoxin of Penicillium roqueforti (PR toxin) are reported. A squamous epithelioma and a uterine sarcoma were histologically confirmed in 2 of 10 albino rats fed PR toxin in a relatively short time (449 and 551 days respectively). Only an adenocarcinoma was histologically proven within a control group of 10 rats in a significantly longer (931 days) time span.
摘要
本文报告了关于罗克福特青霉一种霉菌毒素（PR毒素）致癌活性的初步结果。在10只白化大鼠中，有2只在相对较短的时间内（分别为449天和551天）摄入PR毒素后，经组织学证实发生了鳞状上皮瘤和子宫肉瘤。在10只大鼠的对照组中，仅在显著更长的时间跨度（931天）内组织学证实有1例腺癌。
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