Fu K, Ma X, Zhang Z
School of Stomatology, Beijing Medical University, Beijing 100081.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1999 Jan;34(1):55-7.
To study what happens after intra-articular injection of corticosteroid.
Synovial fluid after intra-articular corticosteroid therapy in temporomandibular joint disorders (TMD) was studied by hematoxylin-eosin, PAS, and Atcian blue staining.
The results were that broken synovial membrane and articular cartilage, lots of synovial lining cells, macrophagocytes, inflammatory cells and free cartilage matrix could be found in the lavage fluid.
The results suggest that drug synovectomy may be one mechanism about intra-articular corticosteroid therapy in TMD, and this therapy could lead to progressive degradation and destruction of the articular cartilage. Arthrocentesis and lavage are needed three to five days after this therapy.
研究关节腔内注射皮质类固醇后会发生什么。
采用苏木精-伊红染色、PAS染色和阿辛蓝染色对颞下颌关节紊乱病（TMD）患者关节腔内注射皮质类固醇治疗后的滑液进行研究。
结果显示，灌洗液中可见滑膜和关节软骨破损，大量滑膜衬里细胞、巨噬细胞、炎性细胞及游离软骨基质。
结果表明，药物性滑膜切除可能是TMD关节腔内皮质类固醇治疗的机制之一，且该治疗可能导致关节软骨进行性退变和破坏。该治疗后3至5天需要进行关节穿刺和灌洗。
