Skibiński G, Zwoliński J, Wieczorek Z
Arch Immunol Ther Exp (Warsz). 1979;27(4):475-80.
The mechanism of action of RIF and RRF on spontaneous rosette formation by human T lymphocytes with SRBC was studied on cells isolated from healthy donors and from patients with active pulmonary tuberculosis. E rosette formation by lymphocytes from healthy donor is inhibited in vitro by RIF. The effect of RIF is reversible since the primary activity of lymphocytes can be restored by contact with RRF. On the other hand, E rosette formation by lymphocytes from tuberculous patients by means of RRF can be depressed by RIF to the starting level. It was found that prostaglandin synthetase inhibitors (indomethacin and RO 20-5720) prevent inhibition or restoration of E rosette activity by RIF and RRF, respectively.
对从健康供体和活动性肺结核患者分离出的细胞，研究了利福平（RIF）和利福喷汀（RRF）对人T淋巴细胞与绵羊红细胞（SRBC）自发形成玫瑰花结的作用机制。利福平在体外可抑制健康供体淋巴细胞形成E玫瑰花结。利福平的作用是可逆的，因为淋巴细胞的原始活性可通过与利福喷汀接触得以恢复。另一方面，利福平可将利福喷汀使结核患者淋巴细胞形成E玫瑰花结的能力抑制至起始水平。研究发现，前列腺素合成酶抑制剂（吲哚美辛和RO 20 - 5720）分别可阻止利福平和利福喷汀对E玫瑰花结活性的抑制或恢复。
