Campbell J H, Rolfe B G
Mol Gen Genet. 1975 Aug 5;139(1):1-8. doi: 10.1007/BF00267990.
The timing of host-cell lysis by coliphage lambda is controlled by two separable systems. The lambdaS gene product acts as a positive effector of lysis while another protein, the lysis regulator, is an inhibitor of lysis. If the continuous function of the lysis regulator is interrupted in phage infected cells immediate lysis ensues. This lysis requires metabolic energy but not S gene activity. In contrast, S protein activity is stimulated by agents which uncouple and which block oxidative phosphorylation. The lysis regulator is thermolabile and several lines of evidence suggest that it may be the lambdarex gene product.
大肠杆菌噬菌体λ对宿主细胞的裂解时间由两个可分离的系统控制。λS基因产物作为裂解的正效应物，而另一种蛋白质，即裂解调节因子，则是裂解的抑制剂。如果在噬菌体感染的细胞中裂解调节因子的持续功能被中断，就会立即发生裂解。这种裂解需要代谢能量，但不需要S基因的活性。相反，S蛋白的活性受到解偶联剂和阻断氧化磷酸化的试剂的刺激。裂解调节因子对热不稳定，有几条证据表明它可能是λrex基因的产物。
