Avilés A, Neri N
Oncology Diseases Research Unit, Oncology Hospital, National Medical Center, IMSS, Mexico, D.F., Mexico.
Clin Lymphoma. 2001 Dec;2(3):173-7. doi: 10.3816/clm.2001.n.023.
To evaluate the risk of acute and late side effects in children whose mothers received chemotherapy during pregnancy for hematological malignancies, we performed an analysis of 84 children with a long-term follow-up. The 84 children in our study were born to mothers with hematological malignancies (29 acute leukemia, 26 Hodgkin's disease, and 29 malignant lymphoma) who received chemotherapy during pregnancy, including 38 during the first trimester. These children were examined for physical health; growth; development; and hematological, cytogenetic, neurological, psychological, and learning disorders. The occurrence of cancer or acute leukemia in these children was also considered. Some of these patients have become parents, and their children were also considered in this analysis. In all of the children studied, including the 12 second-generation children, the birth weight was normal; learning and educational performance were normal; and no congenital, neurological, or psychological abnormalities were observed. With a median follow-up of 18.7 years (range, 6-29 years), no cancer or acute leukemia has been observed. These results confirm our previous reports, suggesting that if a pregnant patient has an aggressive hematological malignancy, chemotherapy at full doses can be safely administered, even during the first trimester, if cure of the hematological malignancy is considered reasonable.
为评估母亲在孕期因血液系统恶性肿瘤接受化疗的儿童发生急性和晚期副作用的风险，我们对84名儿童进行了长期随访分析。我们研究中的84名儿童的母亲患有血液系统恶性肿瘤（29例急性白血病、26例霍奇金病和29例恶性淋巴瘤），她们在孕期接受了化疗，其中38例在孕早期接受化疗。对这些儿童进行了身体健康、生长发育、血液学、细胞遗传学、神经学、心理学和学习障碍方面的检查。还考虑了这些儿童患癌症或急性白血病的情况。其中一些患者已为人父母，他们的孩子也纳入了本分析。在所有研究的儿童中，包括12名第二代儿童，出生体重正常，学习和教育表现正常，未观察到先天性、神经学或心理学异常。中位随访时间为18.7年（范围6 - 29年），未观察到癌症或急性白血病。这些结果证实了我们之前的报告，表明如果一名孕妇患有侵袭性血液系统恶性肿瘤，若认为治愈该血液系统恶性肿瘤合理，即使在孕早期也可安全给予全剂量化疗。
