灵芝对小鼠肝脏和肾脏的保护作用评估。

Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice.

作者信息

Shieh Y H, Liu C F, Huang Y K, Yang J Y, Wu I L, Lin C H, Li S C

机构信息

Department of Family Medicine, Taipei Medical University Hospital, Taiwan.

出版信息

Am J Chin Med. 2001;29(3-4):501-7. doi: 10.1142/S0192415X01000526.

DOI:10.1142/S0192415X01000526

PMID:11789593

Abstract

The antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation had been studied. In order to further investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide induced hepatic and renal damages.

摘要

灵芝热水提取物对乙醇诱导的自由基生成的抗氧化作用已得到研究。为了进一步探究灵芝对肝脏和肾脏的保护机制，测定了脂质过氧化率。灵芝热水提取物对小鼠肝脏和肾脏脂质过氧化呈剂量依赖性抗氧化作用；我们的结果表明，乙醇给药组肝脏和肾脏匀浆中的丙二醛水平高于灵芝治疗组。得出的结论是，灵芝对肝脏和肾脏的保护机制，可能至少部分归因于其显著的超氧化物清除作用。灵芝提取物可以保护肝脏和肾脏免受超氧化物诱导的肝脏和肾脏损伤。