抗肝纤维化特征性成分的研究进展与实验进展
: Current advancements of characteristic components and experimental progress in anti-liver fibrosis.
作者信息
Peng Haoyuan, Zhong Lei, Cheng Lin, Chen Lu, Tong Rongsheng, Shi Jianyou, Bai Lan
机构信息
The State Key Laboratory of Southwestern Chinese Medicine Resources, Department of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Front Pharmacol. 2023 Jan 9;13:1094405. doi: 10.3389/fphar.2022.1094405. eCollection 2022.
is a well-known herbal medicine with a variety of pharmacological effects. Studies have found that has pharmacological effects such as antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. The main active components of include triterpenoids, polysaccharides, sterols, peptides and other bioactive components. Among them, the triterpenoids and polysaccharide components of have a wide range of anti-liver fibrotic effects. Currently, there have been more reviews and studies on the antioxidant, antitumor, and anti-aging properties of . Based on the current trend of increasing number of liver fibrosis patients in the world, we summarized the role of extract in anti-liver fibrosis and the effect of extract on liver fibrosis induced by different pathogenesis, which were discussed and analyzed. Research and development ideas and references are provided for the subsequent application of extracts in anti-liver fibrosis treatment.
是一种具有多种药理作用的著名草药。研究发现,具有抗氧化、抗肿瘤、抗衰老、抗肝纤维化和免疫调节等药理作用。的主要活性成分包括三萜类、多糖、甾醇、肽等生物活性成分。其中,的三萜类和多糖成分具有广泛的抗肝纤维化作用。目前,关于的抗氧化、抗肿瘤和抗衰老特性已有更多综述和研究。基于目前世界上肝纤维化患者数量不断增加的趋势,我们总结了提取物在抗肝纤维化中的作用以及提取物对不同发病机制诱导的肝纤维化的影响,并进行了讨论和分析。为提取物后续在抗肝纤维化治疗中的应用提供研发思路和参考。
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