重复注射阿托品对纯种马心率变异性的影响。

Effects of repeated atropine injection on heart rate variability in Thoroughbred horses.

作者信息

Ohmura H, Hiraga A, Aida H, Kuwahara M, Tsubone H

机构信息

Equine Science Division, Hidaka Yearling Training Farm of Japan Racing Association, Urakawa-gun, Hokkaido, Japan.

出版信息

J Vet Med Sci. 2001 Dec;63(12):1359-60. doi: 10.1292/jvms.63.1359.

DOI:10.1292/jvms.63.1359

PMID:11789620

Abstract

To investigate the effects of repeated atropine injection on heart rate (HR) variability in resting Thoroughbred horses, two microg/ kg of atropine as parasympathetic nervous blockade was injected intravenously every 6 min to a total of 8 microg/kg after intravenous administration of 0.2 mg/kg of propranolol as sympathetic nervous blockade. We recorded electrocardiograms and obtained the HR, then evaluated variation in HR from the power spectrum in terms of low frequency (LF, 0.01-0.07 Hz) power and high frequency (HF, 0.07-0.6 Hz) power. Administration of atropine decreased parasympathetic nervous activity in a dose-dependent manner, affecting first the LF power, then the HF power and finally HR. These responses may provide valuable information for evaluating autonomic nervous activity in Thoroughbred horses.

摘要

为研究重复注射阿托品对安静状态下纯血马心率（HR）变异性的影响，在静脉注射0.2mg/kg普萘洛尔作为交感神经阻滞之后，每隔6分钟静脉注射2μg/kg阿托品作为副交感神经阻滞，总量达8μg/kg。我们记录心电图并获取心率，然后根据低频（LF，0.01 - 0.07Hz）功率和高频（HF，0.07 - 0.6Hz）功率从功率谱评估心率变化。阿托品给药以剂量依赖性方式降低副交感神经活动，首先影响低频功率，然后是高频功率，最后是心率。这些反应可能为评估纯血马的自主神经活动提供有价值的信息。