利用天然蚊虫传播系统，用罗斯河病毒和巴马森林病毒对澳大利亚帚尾袋貂（Trichosurus vulpecula，袋貂科：有袋目）进行实验性感染。

Experimental infection of Australian brushtail possums, Trichosurus vulpecula (Phalangeridae: Marsupialia), with Ross River and Barmah Forest viruses by use of a natural mosquito vector system.

作者信息

Boyd A M, Hall R A, Gemmell R T, Kay B H

机构信息

Queensland Institute of Medical Research and University of Queensland, Tropical Health Program, St. Lucia, Australia.

出版信息

Am J Trop Med Hyg. 2001 Dec;65(6):777-82. doi: 10.4269/ajtmh.2001.65.777.

DOI:10.4269/ajtmh.2001.65.777

PMID:11791974

Abstract

Brushtail possums, Trichosurus vulpecula Kerr, were experimentally infected with Ross River (RR) or Barmah Forest (BF) virus by Aedes vigilax (Skuse) mosquitoes. Eight of 10 animals exposed to RR virus developed neutralizing antibody, and 3 possums developed high viremia for < 48 hr after infection, sufficient to infect recipient mosquitoes. Two of 10 animals exposed to BF virus developed neutralizing antibody. Both infected possums maintained detectable neutralizing antibody to BF for at least 45 days after infection (log neutralization index > 2.0 at 45 days). Eight possums did not develop neutralizing antibody to BF despite exposure to infected mosquitoes. These results suggest that T. vulpecula may potentially act as a reservoir species for RR in urban areas. However, T. vulpecula infected with BF do not develop viremia sufficient to infect mosquitoes and are unlikely to be important hosts for BF.

摘要

帚尾袋貂（Trichosurus vulpecula Kerr）通过警觉伊蚊（Aedes vigilax，Skuse）感染了罗斯河（RR）病毒或巴马森林（BF）病毒。暴露于RR病毒的10只动物中有8只产生了中和抗体，3只袋貂在感染后<48小时出现了高病毒血症，足以感染受体蚊子。暴露于BF病毒的10只动物中有2只产生了中和抗体。两只受感染的袋貂在感染后至少45天内都保持可检测到的针对BF的中和抗体（45天时对数中和指数>2.0）。尽管暴露于受感染的蚊子，仍有8只袋貂未产生针对BF的中和抗体。这些结果表明，帚尾袋貂在城市地区可能潜在地作为RR的储存宿主物种。然而，感染BF的帚尾袋貂不会产生足以感染蚊子的病毒血症，不太可能是BF的重要宿主。