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肺泡蛋白沉积症的诊断与管理:电子显微镜的作用

Diagnosis and management of alveolar proteinosis: the rôle of electron microscopy.

作者信息

Costello J F, Moriarty D C, Branthwaite M A, Turner-Warwick M, Corrin B

出版信息

Thorax. 1975 Apr;30(2):121-32. doi: 10.1136/thx.30.2.121.

DOI:10.1136/thx.30.2.121
PMID:1179307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC470256/
Abstract

The diagnosis and management of three cases of pulmonary alveolar proteinosis are described. The electron microscopic appearances of lung biopsy material, lung washings, and sputum and the value of this method of sputum examination in extremely ill patients are demonstrated. The practical details of controlled volume bronchial lavage are described and the good clinical and physiological response of patients reported. The findings have been compared with those of experimental pulmonary alveolar proteinosis, and the pathogenesis of the condition is discussed.

摘要

本文描述了三例肺泡蛋白沉积症的诊断与治疗。展示了肺活检材料、肺灌洗物及痰液的电子显微镜表现,以及这种痰液检查方法在重症患者中的价值。描述了控制性容量支气管灌洗的实际操作细节,并报告了患者良好的临床和生理反应。将这些发现与实验性肺泡蛋白沉积症的结果进行了比较,并对该病的发病机制进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/13e4651f4a81/thorax00140-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/55757659b8f0/thorax00140-0003-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/b20af540115c/thorax00140-0003-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/9a70403c8499/thorax00140-0004-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/dc45f74addfe/thorax00140-0005-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/5eadc6473c24/thorax00140-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/650be1f51622/thorax00140-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/97d8e28cd958/thorax00140-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/dfaf5870684e/thorax00140-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/74b1ca06c7ca/thorax00140-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/13e4651f4a81/thorax00140-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/55757659b8f0/thorax00140-0003-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/b20af540115c/thorax00140-0003-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/9a70403c8499/thorax00140-0004-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/dc45f74addfe/thorax00140-0005-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/5eadc6473c24/thorax00140-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/650be1f51622/thorax00140-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/97d8e28cd958/thorax00140-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/dfaf5870684e/thorax00140-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/74b1ca06c7ca/thorax00140-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/470256/13e4651f4a81/thorax00140-0011-a.jpg

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Reply to McCarthy : Lipid-Laden Macrophages Are Not Diagnostic of Pulmonary Alveolar Proteinosis Syndrome and Can Indicate Lung Injury.对麦卡锡的回应:富含脂质的巨噬细胞并非肺泡蛋白沉积症综合征的诊断依据,且可提示肺损伤。

本文引用的文献

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