Fossi M C, Casini S, Marsili L, Ausili A, di Sciara G N
Department of Animal Biology and Marine Ecology, University of Messina, Italy.
Ann N Y Acad Sci. 2001 Dec;948:67-74. doi: 10.1111/j.1749-6632.2001.tb03987.x.
Man-made endocrine disrupting chemicals (EDCs) range across all continents and oceans; some geographic areas are potentially more threatened than others: one of these is the Mediterranean Sea. This basin has limited exchange of water with the Atlantic Ocean and is surrounded by some of the most heavily populated and industrialized countries in the world. Accordingly, levels of some xenobiotics are much higher here than in other seas and oceans. In this research the unexplored hypothesis that Mediterranean top predator species (such as large pelagic fish and marine mammals) are potentially at risk due to EDCs is investigated. Here we illustrate the development of sensitive biomarkers (Vitellogenin, Zona Radiata proteins) for evaluation of toxicological risk in top marine predators (Xiphias gladius, Thunnus thynnus thynnus), and nonlethal techniques, such as nondestructive biomarkers (BPMO activities in skin biopsy), for the hazard assessment of threatened species exposed to EDCs, such as marine mammals (Stenella coeruleoalba, Tursiops truncatus, Delphinus delphis, and Balaenoptera physalus).
人造内分泌干扰化学物质（EDCs）遍布各大洲和海洋；一些地理区域可能比其他区域受到的威胁更大：其中之一就是地中海。该海域与大西洋的水体交换有限，且周边环绕着世界上一些人口最为密集和工业化程度最高的国家。因此，这里某些外来生物的含量比其他海洋要高得多。在本研究中，我们对一个尚未探索的假设进行了调查，即地中海顶级捕食者物种（如大型远洋鱼类和海洋哺乳动物）可能因EDCs而面临风险。在此，我们阐述了用于评估顶级海洋捕食者（剑鱼、大西洋蓝鳍金枪鱼）毒理学风险的敏感生物标志物（卵黄蛋白原、放射带蛋白）的开发，以及用于对暴露于EDCs的受威胁物种（如海洋哺乳动物（条纹海豚、宽吻海豚、真海豚和长须鲸））进行危害评估的非致死技术，如非破坏性生物标志物（皮肤活检中的BPMO活性）。
