Reed M D, Perry E B, Fennell S J, Brissie W O, Ball W D
Chemotherapy. 1979;25(6):336-45. doi: 10.1159/000237861.
Eight antibiotics, alone and in selected combinations, were evaluated for stability and compatibility in a protein hydrolysate parenteral nutrition solution. Samples were stored under varying conditions and evaluated at 12-hour intervals over a period of 24--48 h. Compatibility and stability were assessed by quantitative bacteriologic assay, pH determinations and visual inspection. In most cases, antibiotics were compatible and stable over the entire study period. Carbenicillin, methicillin in combination with gentamicin, and tobramycin in combination with cephalothin or methicillin, exhibited a gradual loss of antibacterial activity after 24 h. These results indicate that the antibiotics studied may be administered in protein hydrolysate parenteral nutrition solutions. This mode of therapy offers a means of combating infection, while maintaining a nutritional source for host defences, tissue repair, and growth.
对八种抗生素单独使用以及特定组合使用时，在蛋白质水解物肠外营养溶液中的稳定性和相容性进行了评估。样品在不同条件下储存，并在24至48小时内每隔12小时进行评估。通过定量细菌学测定、pH值测定和目视检查来评估相容性和稳定性。在大多数情况下，抗生素在整个研究期间都是相容且稳定的。羧苄青霉素、甲氧西林与庆大霉素联用，以及妥布霉素与头孢噻吩或甲氧西林联用，在24小时后抗菌活性逐渐丧失。这些结果表明，所研究的抗生素可以在蛋白质水解物肠外营养溶液中给药。这种治疗方式提供了一种对抗感染的手段，同时为宿主防御、组织修复和生长维持营养来源。
