Schuetz D H, King J C
Am J Hosp Pharm. 1978 Jan;35(1):33-44.
The compatibility and stability of the following additives in an 8% amino acids and 50% dextrose solution intended for total parenteral nutrition were studied: potassium phosphate, calcium gluconate, magnesium sulfate, multiple vitamine mixtures, folic acid, cyanocobalamin, phytonadione, insulin, ampicillin, cephalothin, kanamycin and gentamicin. In addition to physical examination, techniques of ultraviolet spectroscopy, thin-layer chromatography and microbiologic assay were used to delineate compatibility characteristics. The principle compatibility problems are generated by elevated concentrations of calcium and phosphate. The efficacy of ampicillin, cephalothin and kanamycin in the amino acids/dextrose solution, with or without additives, did not appear to be significantly different from control samples prepared in sterile water. It appeared that gentamicin might be significantly more effective in the test solutions than in sterile water, but further investigation is needed to verify this. A comprehensive study of the stability of vitamins in parenteral nutrient solutions must be made before a final judgment can be made.
研究了以下添加剂在用于全胃肠外营养的8%氨基酸和50%葡萄糖溶液中的相容性和稳定性：磷酸钾、葡萄糖酸钙、硫酸镁、多种维生素混合物、叶酸、氰钴胺、维生素K、胰岛素、氨苄西林、头孢噻吩、卡那霉素和庆大霉素。除了进行物理检查外，还使用了紫外光谱法、薄层色谱法和微生物测定技术来描述相容性特征。主要的相容性问题是由钙和磷酸盐浓度升高引起的。在含或不含添加剂的氨基酸/葡萄糖溶液中，氨苄西林、头孢噻吩和卡那霉素的效力似乎与在无菌水中制备的对照样品没有显著差异。似乎庆大霉素在测试溶液中可能比在无菌水中显著更有效，但需要进一步研究来证实这一点。在做出最终判断之前，必须对胃肠外营养液中维生素的稳定性进行全面研究。
