Weber Cora, Arck Petra, Mazurek Birgit, Klapp Burghard F
Clinic for Internal Medicine-Psychosomatics, Charité Campus Virchow Clinic, Medical School of the Humboldt University, Augustenburger Platz 1, 13353, Berlin, Germany.
J Psychosom Res. 2002 Jan;52(1):29-33. doi: 10.1016/s0022-3999(01)00281-1.
Tinnitus often entails severe psychological distress. Reversely, tinnitus may be considered as a chronic stressor. Based on this hypothesis, we investigated whether improving stress-managing capabilities would influence psychological and stress-related immunological parameters in chronic tinnitus sufferers.
Tinnitus (TPs, n=26) and non-tinnitus participants (NTPs, n=13) took part in a standardised 10-week relaxation program. An additional group of tinnitus sufferers (n=18), randomly assigned to a waiting list, served as control (TC) subjects. Mood, perceived stress, global quality of life, and tinnitus disturbance were assessed before and after the intervention. The stress-sensitive immunological parameters TNF-alpha, IL-6, and IL-10 were measured before, during, and at the end of the intervention.
The program resulted in a significantly decreased perception of stress, anxious depression, anger, and tinnitus disturbance, paralleled by a reduction of TNF-alpha. No alterations were noted for IL-6 or IL-10. For the NTPs and TCs, no relevant psychological or immune changes could be observed.
The data suggest that (1) the training offered improved stress-managing capabilities in chronic tinnitus sufferers, and (2) TNF-alpha may be conceived as a stress marker.
耳鸣常伴有严重的心理困扰。反之，耳鸣可被视为一种慢性应激源。基于这一假设，我们研究了改善压力管理能力是否会影响慢性耳鸣患者的心理及与压力相关的免疫参数。
耳鸣患者（TPs，n = 26）和非耳鸣参与者（NTPs，n = 13）参加了一个为期10周的标准化放松项目。另一组耳鸣患者（n = 18）被随机分配到等待名单中，作为对照（TC）组。在干预前后评估情绪、感知压力、总体生活质量和耳鸣干扰情况。在干预前、干预期间和干预结束时测量应激敏感免疫参数肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）。
该项目导致压力感知、焦虑抑郁、愤怒和耳鸣干扰显著降低，同时TNF-α也有所下降。IL-6或IL-10未发现变化。对于NTPs和TCs，未观察到相关的心理或免疫变化。
数据表明：（1）所提供的训练提高了慢性耳鸣患者的压力管理能力；（2）TNF-α可被视为一种压力标志物。
