Hauswirth J W, Nair P P
Am J Clin Nutr. 1975 Oct;28(10):1087-94. doi: 10.1093/ajcn/28.10.1087.
Male Sprague-Dawley rats maintained for a period of 6 or 12 weeks on a basal vitamin E-dificient diet consisting of 70% sucrose, 20% vitamin-free casein, 4% tocopherol stripped lard, 4% salt mixture, and 2% tocopherol-free vitamin fortification mixture were used to compare two sets of commonly used salt mixtures (salt mixtures USP XIV versus Briggs' salt mixture) and two sets of vitamin fortification mixtures (NBC vitamin fortification mixture versus that of Weglicki). Among the rats maintained on the deficient diets for 6 weeks, only those that received the combination of salt mixture USP XIV and vitamin fortification mixture of Weglicki showed a significantly lower level of hepatic catalase activity compared to the corresponding control animals. While there were no significant changes in microsomal cytochromes at this time period, after 12 weeks on the deficient diet, a significant depression in these cytochromes was noted in all experimental groups except the one on salt mixture USP XIV and NBC vitamin fortification mixture. A similar decrease in hepatic catalase was observed in deficient animals at 12 weeks. Since the most striking differences in these diets are in their content of iron and menaquinone, it appears that these two dietary constituents may interact in modulating the effect of vitamin E on hepatic hemeproteins.
将雄性斯普拉格-道利大鼠置于缺乏维生素E的基础饮食中6周或12周，该基础饮食由70%蔗糖、20%无维生素酪蛋白、4%脱生育酚猪油、4%盐混合物和2%无生育酚维生素强化混合物组成，以此来比较两组常用的盐混合物（美国药典第十四版盐混合物与布里格斯盐混合物）以及两组维生素强化混合物（美国国家广播公司维生素强化混合物与韦格利茨基的维生素强化混合物）。在维持缺乏饮食6周的大鼠中，只有那些接受美国药典第十四版盐混合物和韦格利茨基维生素强化混合物组合的大鼠，与相应的对照动物相比，肝脏过氧化氢酶活性水平显著降低。虽然在此时间段微粒体细胞色素没有显著变化，但在缺乏饮食12周后，除了接受美国药典第十四版盐混合物和美国国家广播公司维生素强化混合物的实验组外，所有实验组的这些细胞色素都出现了显著降低。在缺乏饮食12周的动物中也观察到肝脏过氧化氢酶有类似的下降。由于这些饮食中最显著的差异在于它们的铁和甲萘醌含量，似乎这两种饮食成分在调节维生素E对肝脏血红素蛋白的作用方面可能存在相互作用。
