Bos P J, Deutman A F
Am J Ophthalmol. 1975 Oct;80(4):573-84. doi: 10.1016/0002-9394(75)90387-6.
An unrecognized acute macular affection occurred in four women, 24 to 35 years old, using oral contraceptives who complained of a sudden decrease of visual acuity or paracentral scotomas. Three patients had bilateral lesions and one patient had unilateral lesions. These lesions consisted of darkish brown-red, wedge-shaped dots in the macula pointing to the fovea. These dots were located mostly on the nasal side to the macula. Biomicroscoby showed these lesions were located in the superficial layers of the retina. The retinal vessels, pigment epithelium, and optic disk showed no distinct pathologic features. Fluorescein angiography, performed repeatedly, showed some questionably dilated perimacular capillaries without leakage in two cases. Static perimetry delineated dense paracentral scotomas. Recovery was slow or absent, confirmed py perimetric observation. Ophthalmoscopic, fluorescein angiography, and perimetric details excluded an affection of the pigment epithelium, the nerve fiber layer, and the optic disk. Since the affection appears to be localized superficially in the retina, we called this specific entity acute macular neuroretinopathy.
4名年龄在24至35岁的女性在使用口服避孕药时出现了一种未被认识的急性黄斑病变，她们主诉视力突然下降或旁中心暗点。3例患者为双侧病变，1例患者为单侧病变。这些病变表现为黄斑区深棕红色楔形小点，指向中央凹。这些小点大多位于黄斑鼻侧。生物显微镜检查显示这些病变位于视网膜表层。视网膜血管、色素上皮和视盘未显示明显病理特征。多次进行的荧光素血管造影显示，2例患者黄斑周围有些可疑扩张的毛细血管，但无渗漏。静态视野检查显示致密的旁中心暗点。视野检查观察证实恢复缓慢或未恢复。检眼镜检查、荧光素血管造影和视野检查细节排除了色素上皮、神经纤维层和视盘的病变。由于这种病变似乎局限于视网膜表层，我们将这种特定病症称为急性黄斑神经视网膜病变。
