Henry L G, Condon R E, Schulte W J, Aprahamian C, DeCosse J J
Ann Surg. 1975 Oct;182(4):511-5. doi: 10.1097/00000658-197510000-00017.
At Wood Veterans Administration Center, 268 patients who had a polypectomy have been followed up to 20 years with semiannual proctosigmoidoscopic and barium enema examinations. For the present review of benign polyp disease, patients having coexisting carcinoma, chronic inflammatory disease, and those lost to followup have been excluded; 154 patients followed for a mean of 7 years comprise the study group. Thirty per cent of patients developed recurrent polyps. The risk of recurrence during the first year was 16 times that expected in a population of similar age and sex, but thereafter diminished steadily. After 48 months risk of polyp recurrence was little higher than the incidence expected in a normal population. Neither patient age, presenting symptoms nor the site or size of the initial polyp(s) were of any prognostic value regarding recurrence. Patients presenting with a villous adenoma or with more than 3 polyps had a significantly increased risk of recurrence may persist indefinitely. The overall incidence of colonic carcinoma may have been increased, but the location of subsequent cancer was not related to the site of a previously excised polyp.
在伍德退伍军人管理中心，268例行息肉切除术的患者接受了长达20年的随访，每半年进行一次直肠乙状结肠镜检查和钡灌肠检查。在本次对良性息肉病的回顾中，排除了合并存在癌症、慢性炎症性疾病的患者以及失访患者；154例平均随访7年的患者组成了研究组。30%的患者出现了息肉复发。第一年复发风险是年龄和性别相似人群预期风险的16倍，但此后风险稳步下降。48个月后，息肉复发风险仅略高于正常人群的发病率。患者年龄、首发症状以及初始息肉的部位或大小对复发均无预后价值。出现绒毛状腺瘤或息肉超过3个的患者复发风险显著增加，且可能会无限期持续。结肠癌的总体发病率可能有所增加，但后续癌症的发生部位与先前切除息肉的部位无关。
