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酒精性组织损伤的分子病理学与临床方面

Molecular pathology and clinical aspects of alcohol-induced tissue injury.

作者信息

Molina Patricia E, McClain Craig, Valla Dominique, Guidot David, Diehl Anna Mae, Lang Charles H, Neuman Manuela

机构信息

Alcohol Research Center and Department of Physiology at Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.

出版信息

Alcohol Clin Exp Res. 2002 Jan;26(1):120-8.

Abstract

Proceedings of a symposium at the 2001 RSA Meeting in Montreal, Canada; organized and co-chaired by Patricia E. Molina and Manuela Neuman. The presentations were (1) Mechanisms of alcohol-induced cell injury by Craig McClain; (2) Cytokines in alcoholic steatohepatitis and non-alcoholic steatohepatitis by Manuela Neuman; (3) Combination of alcohol and hepatitis C virus and liver injury by Dominique Valla; (4) Chronic ethanol exposure potentiates lipopolysaccharide liver injury, despite inhibiting Jun N-Terminal kinase and caspase 3 activation by Anna Mae Diehl; (5) Glutathione homeostasis in alcoholism: Role in alveolar epithelial barrier and lung injury by David M. Guidot; (6) Metabolic and inflammatory contribution of alcohol to trauma-induced tissue injury by Patricia E. Molina; (7) Growth factor and protein synthesis dysregulation: Role in alcoholic myopathy by Charles H. Lang.

摘要

2001年在加拿大蒙特利尔举行的RSA会议上一场研讨会的会议记录;由帕特里夏·E·莫利纳和曼努埃拉·诺伊曼组织并共同主持。发言内容包括:(1)克雷格·麦克莱恩所讲的酒精诱导细胞损伤的机制;(2)曼努埃拉·诺伊曼所讲的酒精性脂肪性肝炎和非酒精性脂肪性肝炎中的细胞因子;(3)多米尼克·瓦拉所讲的酒精与丙型肝炎病毒的联合作用及肝损伤;(4)安娜·梅·迪尔所讲的长期乙醇暴露增强脂多糖肝损伤,尽管其抑制了Jun N末端激酶和半胱天冬酶3的激活;(5)大卫·M·吉多所讲的酒精中毒中的谷胱甘肽稳态:在肺泡上皮屏障和肺损伤中的作用;(6)帕特里夏·E·莫利纳所讲的酒精对创伤诱导组织损伤的代谢和炎症作用;(7)查尔斯·H·朗所讲的生长因子和蛋白质合成失调:在酒精性肌病中的作用。

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