Winther Birgit, Gwaltney Jack M, Humphries John E, Hendley J Owen
University of Virginia Health System, Department of Otolaryngology, Head & Neck Surgery, Charlottesville, VA, 22908, USA.
Clin Infect Dis. 2002 Mar 1;34(5):708-10. doi: 10.1086/338716. Epub 2002 Jan 25.
To determine whether adherent material found on the walls of the paranasal sinuses during common colds might be fibrin clot, we examined the nasal fluid (a surrogate for sinus secretion) of 11 young adults with experimentally induced rhinovirus colds and that of 4 control subjects for the presence of fibrin. The mean concentration (+/- the standard error) of insoluble fibrin (measured as D-dimer) in subjects with rhinovirus colds increased from a baseline level of 0.8+/-0.4 microgram/mL to a peak of 2.4+/-0.7 microgram/mL (P=.0008) on day 4 after inoculation of the virus, but the fibrin concentration remained at baseline levels in the 4 uninfected control subjects.
为了确定在普通感冒期间于鼻窦壁上发现的附着物质是否可能是纤维蛋白凝块，我们检测了11名因实验性感染鼻病毒而患感冒的年轻成年人以及4名对照受试者的鼻分泌物（作为鼻窦分泌物的替代物）中是否存在纤维蛋白。感染鼻病毒的受试者中，不可溶性纤维蛋白（以D - 二聚体衡量）的平均浓度（±标准误）从接种病毒后第4天的基线水平0.8±0.4微克/毫升升至峰值2.4±0.7微克/毫升（P = 0.0008），但4名未感染的对照受试者的纤维蛋白浓度保持在基线水平。
