Turner B W, Cail W S, Hendley J O, Hayden F G, Doyle W J, Sorrentino J V, Gwaltney J M
Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville.
J Allergy Clin Immunol. 1992 Sep;90(3 Pt 2):474-8. doi: 10.1016/0091-6749(92)90172-x.
Six (18%) of 34 healthy, asymptomatic young adults had mucosal thickening or fluid in the paranasal sinuses on screening magnetic resonance imaging (MRI) examination. When 19 of these subjects were challenged with rhinovirus, 18 became infected. Twelve of the 18 infected subjects had technically satisfactory serial MRI examinations, and four (33%) of these developed MRI abnormalities of the ethmoid or antral sinuses that were temporally associated with the acute infection. The mean total nasal secretion weights were 22 gm/5 days in the four subjects whose MRI abnormalities were associated with the acute infection compared with 5.5 gm/5 days in the eight subjects who had normal MRI examinations during the acute infection (p = 0.06). Abnormalities of the paranasal sinuses, which were associated with increased volumes of nasal secretion, were detected by MRI examination during rhinovirus infection. These abnormalities may have a role in the pathogenesis of acute sinusitis associated with colds.
在34名健康、无症状的年轻成年人中，有6人（18%）在筛查磁共振成像（MRI）检查时出现鼻窦黏膜增厚或积液。当其中19名受试者感染鼻病毒时，18人被感染。18名受感染受试者中有12人进行了技术上令人满意的系列MRI检查，其中4人（33%）出现筛窦或上颌窦的MRI异常，这些异常在时间上与急性感染相关。与急性感染期间MRI检查正常的8名受试者相比，4名MRI异常与急性感染相关的受试者的平均总鼻分泌物重量为22克/5天，而这8名受试者为5.5克/5天（p = 0.06）。在鼻病毒感染期间，通过MRI检查发现鼻窦异常与鼻分泌物增多有关。这些异常可能在与感冒相关的急性鼻窦炎发病机制中起作用。
