Yuen P Wing, Man M, Lam K Yin, Kwong Y Lam
Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
J Clin Pathol. 2002 Jan;55(1):58-60. doi: 10.1136/jcp.55.1.58.
To evaluate the clinicopathological significance of p16 expression in the surgical management of squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx, and larynx.
p16 expression in 225 head and neck squamous cell carcinomas (HNSCCs) was studied using an immunohistochemical method and paraffin wax embedded tumour tissues. Associations between p16 expression and clinicopathological features were investigated.
Decreased p16 expression was found in 48% of the tumours. There was a higher frequency of decreased p16 expression in tumours of the larynx compared with those from the pharynx and oral cavity. There was a significant correlation between decreased p16 expression and more advanced T stage. There was no significant correlation between p16 expression and sex, age, tumour grade, nodal metastasis, recurrence, or survival.
There was a high frequency of downregulation of p16 expression in HNSCC. Tumours of the larynx had a significantly higher frequency of weak p16 expression compared with tumours of the oral cavity and pharynx. Downregulation of p16 contributed to cellular proliferation, resulting locally in a more advanced tumour. It had no prognostic significance for nodal metastasis and survival.
评估p16表达在口腔、口咽、下咽和喉鳞状细胞癌手术治疗中的临床病理意义。
采用免疫组织化学方法，对225例头颈部鳞状细胞癌（HNSCC）石蜡包埋的肿瘤组织进行p16表达研究，并调查p16表达与临床病理特征之间的关联。
48%的肿瘤中发现p16表达降低。与来自咽和口腔的肿瘤相比，喉肿瘤中p16表达降低的频率更高。p16表达降低与更晚期的T分期之间存在显著相关性。p16表达与性别、年龄、肿瘤分级、淋巴结转移、复发或生存率之间无显著相关性。
HNSCC中p16表达下调的频率较高。与口腔和咽肿瘤相比，喉肿瘤中p16弱表达的频率显著更高。p16下调促进细胞增殖，导致局部肿瘤进展更严重。它对淋巴结转移和生存率无预后意义。
