Donnelly Martin J, Simard Frédéric, Lehmann Tovi
Division of Parasite and Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA., Liverpool, UK.
Trends Parasitol. 2002 Feb;18(2):75-80. doi: 10.1016/s1471-4922(01)02198-5.
The rationales given for studies of the population genetics of vectors are usually: (1) to predict the spread of genes, such as genes conferring insecticide resistance or possibly refractoriness to parasites and (2) to reveal novel insights into the epidemiology and transmission of vector-borne disease. The successful genetic transformation of mosquitoes has highlighted the need for a critical assessment of the rapidly accumulating body of data on the population genetics of malaria vectors. This article assesses how successful molecular genetic techniques have been in revealing new population patterns.
（1）预测基因的传播，如赋予抗杀虫剂能力或可能对寄生虫具有不敏感性的基因；（2）揭示关于病媒传播疾病的流行病学和传播的新见解。蚊子的成功基因改造突出表明，需要对迅速积累的关于疟疾媒介种群遗传学的数据进行批判性评估。本文评估了分子遗传技术在揭示新的种群模式方面取得了多大成功。
