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[海德琴对需要洋地黄治疗的脑血管功能不全患者的治疗。一项双盲研究的结果(作者译)]

[Hydergin therapy of cerebrovascular insufficiency in patients requiring digitalis. Results of a double-blind study (author's transl)].

作者信息

Dennler H J, Bachmann H

出版信息

MMW Munch Med Wochenschr. 1979 Nov 30;121(48):1615-8.

PMID:118360
Abstract

In a controlled double-blind trial in 80 patients with cerebrovascular and cardiac insufficiency the differentiated effect of a combination therapy with cardiac glycosides and Hydergin were studied both with regard to parameters of cerebral organic and cardiac performance. Two randomized collectives of patients with an average age of 63 years were compared with each other for this purpose. They received either acetyldigoxin (0.4 mg/day) alone or in combination with Hydergin (3 mg/day). Duration of treatment was 8 weeks altogether. The single treatment with the cardiac glycoside alone does not lead to a satisfactory improvement in the symptoms of cerebral attacks. The results presented of this study support the necessity in these patients of an internist basic therapy in combination with a preparation like Hydergin acting favorably on cerebral metabolism.

摘要

在一项针对80例脑血管和心脏功能不全患者的对照双盲试验中,研究了强心苷与海德金联合治疗在脑器质性和心脏功能参数方面的差异作用。为此,将两个平均年龄为63岁的随机患者群体进行了相互比较。他们分别接受单独的乙酰地高辛(0.4毫克/天)或与海德金(3毫克/天)联合使用。治疗总时长为8周。单独使用强心苷进行单一治疗并不能使脑卒症状得到令人满意的改善。本研究呈现的结果支持了这些患者采用内科基础治疗并联合使用对脑代谢有良好作用的制剂(如海德金)的必要性。

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