Higaki Shuichi, Kitagawa Taro, Morohashi Masaaki, Yamagishi Takayoshi
Department of Dermatology, Faculty of Medicine, Toyama Medical & Pharmaceutical University, Sugitani, Japan.
J Dermatol. 2002 Jan;29(1):20-2. doi: 10.1111/j.1346-8138.2002.tb00159.x.
We studied the effects of minocycline on Propionibacterium granulosum. P. granulosum lipase activity was detected from acne lesions. Production of propionic and butyric acids by P. granulosum was well suppressed by all tested media with added minocycline; the higher the concentration of minocycline in the medium, the less of these acids was produced. It appeared that the decrease in these acids due to minocycline was greater in P. granulosum than in P. acnes. Although the influence of P. granulosum on acne lesions might be feebler than that of P. acnes, we should not neglect its presence. More research is needed to elucidate the relationship between the two species in acne lesions.
我们研究了米诺环素对颗粒丙酸杆菌的影响。从痤疮皮损中检测到颗粒丙酸杆菌的脂肪酶活性。添加米诺环素的所有测试培养基均能很好地抑制颗粒丙酸杆菌产生丙酸和丁酸；培养基中米诺环素的浓度越高，这些酸的产生量就越少。似乎米诺环素导致的这些酸的减少在颗粒丙酸杆菌中比在痤疮丙酸杆菌中更明显。尽管颗粒丙酸杆菌对痤疮皮损的影响可能比痤疮丙酸杆菌弱，但我们不应忽视它的存在。需要更多的研究来阐明这两种菌在痤疮皮损中的关系。
