颗粒丙酸杆菌和痤疮丙酸杆菌脂肪酶活性的影响。

Effect of lipase activities of Propionibacterium granulosum and Propionibacterium acnes.

作者信息

Higaki S, Nakamura M, Kitagawa T, Morohashi M, Yamagishi T

机构信息

Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan.

出版信息

Drugs Exp Clin Res. 2001;27(5-6):161-4.

PMID:11951573

Abstract

We studied the lipase activities of Propionibacterium granulosum, P. acnes and the suppression of these activities by Jumi-haidoku-to (JHT). Lipase activity of P. acnes biotype III (BIII) was strongest, while that of P. granulosum was faintly expressed. Compared with the control medium, the production of propionic and butyric acids was suppressed by all the tested mediums combined with JHT. The decrease in these acids produced by JHT was significantly higher in P. granulosum than in P. acnes. Although P. acnes BIII may produce a strong effect on acne, the presence of P. granulosum should not be ignored. Further research is required on the correlation between P. acnes and P. granulosum.

摘要

我们研究了颗粒丙酸杆菌、痤疮丙酸杆菌的脂肪酶活性以及十味败毒汤（JHT）对这些活性的抑制作用。痤疮丙酸杆菌生物III型（BIII）的脂肪酶活性最强，而颗粒丙酸杆菌的脂肪酶活性表达较弱。与对照培养基相比，所有测试培养基与JHT联合使用时，丙酸和丁酸的产生均受到抑制。JHT使颗粒丙酸杆菌产生的这些酸的减少量显著高于痤疮丙酸杆菌。尽管痤疮丙酸杆菌BIII可能对痤疮产生强烈影响，但颗粒丙酸杆菌的存在也不容忽视。需要进一步研究痤疮丙酸杆菌与颗粒丙酸杆菌之间的相关性。