Finsterbush A, Friedman B
J Bone Joint Surg Am. 1975 Oct;57(7):949-56.
Unilateral sensory denervation of the hind limb in a group of rabbits caused progressive atrophy of cells in all structures of the knee joint, whether or not the joint was protected by a plaster cast. Immobilization without denervation caused proliferative changes, first in the synovium and then in the articular cartilage. The initial changes in the articular cartilage following sensory denervation occurred in the middle layers, suggesting that nutritional deficiency was involved. In contrast, the first changes in the cartilage of intact immobilized limbs occurred in the superficial layers and were most likely of mechanical origin.
一组兔子后肢的单侧感觉神经去支配导致膝关节所有结构中的细胞进行性萎缩，无论关节是否用石膏固定保护。无神经去支配的固定导致增殖性变化，首先在滑膜，然后在关节软骨。感觉神经去支配后关节软骨的最初变化发生在中间层，提示涉及营养缺乏。相比之下，完整固定肢体软骨的最初变化发生在表层，很可能是机械性起源。
