手术诱导的膝关节不稳定对大鼠膝关节软骨的影响。

Williams J M, Felten D L, Peterson R G, O'Connor B L

J Anat. 1982 Jan;134(Pt 1):103-9.

Degenerative lesions in the articular cartilage were present following transection of the anterior cruciate ligament in the rat. These lesions included surface disruptions, a reduction in matrix proteoglycans, and cellular changes and therefore were similar to lesions seen in dogs following transection of the anterior cruciate ligament as well as lesions seen in other mechanical derangement models. Lesions were more frequently encountered in animals that had been exercised on a treadmill. This suggests that the rat knee joint may be a useful small animal model in studying the effect of mechanical derangement on articular tissues.

大鼠前交叉韧带横断后，关节软骨出现退行性病变。这些病变包括表面破坏、基质蛋白聚糖减少和细胞变化，因此与犬前交叉韧带横断后出现的病变以及其他机械性紊乱模型中所见的病变相似。在跑步机上运动的动物中更常出现病变。这表明大鼠膝关节可能是研究机械性紊乱对关节组织影响的有用的小动物模型。