表没食子儿茶素没食子酸酯（EGCG）对肿瘤侵袭和血管生成的抑制作用，EGCG是绿茶的主要成分。
Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea.
作者信息
Jung Y D, Ellis L M
机构信息
Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju, Korea.
出版信息
Int J Exp Pathol. 2001 Dec;82(6):309-16. doi: 10.1046/j.1365-2613.2001.00205.x.
Abstract
Epidemiological studies have suggested that consumption of green tea may decrease cancer risk. In addition, abundant pre-clinical data from several laboratories have provided convincing evidence that polyphenols present in green tea afford protection against cancer in both in vivo and in vitro studies. Recently, epigallocatechin gallate (EGCG), a putative chemopreventive agent and a major component of green tea, was reported to inhibit tumour invasion and angiogenesis, processes that are essential for tumour growth and metastasis. Understanding the basic principles by which EGCG inhibits tumour invasion and angiogenesis may lead to the development of new therapeutic strategies, in addition to supporting the role of green tea as a cancer chemopreventive agent.
摘要
流行病学研究表明，饮用绿茶可能降低患癌风险。此外，多个实验室提供的大量临床前数据表明，绿茶中的多酚类物质在体内和体外研究中均具有抗癌作用。最近，表没食子儿茶素没食子酸酯（EGCG）作为一种潜在的化学预防剂和绿茶的主要成分，被报道可抑制肿瘤侵袭和血管生成，而这两个过程对肿瘤生长和转移至关重要。了解EGCG抑制肿瘤侵袭和血管生成的基本原理，除了能支持绿茶作为癌症化学预防剂的作用外，还可能带来新治疗策略的发展。
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