McKeran R O, Slavin G, Andrews T M, Ward P, Mair W G
J Clin Pathol. 1975 Aug;28(8):659-63. doi: 10.1136/jcp.28.8.659.
Changes in muscle fibre type in hypothyroid myopathy were studied by serial percutaneous needle biopsy of vastus lateralis before and during treatment with L-thyroxine. A type II fibre atrophy and loss was found, which correlated with the clinical and biochemical evidence of a myopathy. The type II fibre atrophy was corrected by L-thyroxine but type II fibre loss was still apparent in severely myopathic patients up to two years after starting treatment. The pathogenesis and significance of type II fibre atrophy and loss are discussed in relation to prognosis.
通过对左股外侧肌进行系列经皮穿刺活检，研究了甲状腺功能减退性肌病患者在左甲状腺素治疗前及治疗期间肌纤维类型的变化。发现Ⅱ型纤维萎缩和缺失，这与肌病的临床和生化证据相关。左甲状腺素可纠正Ⅱ型纤维萎缩，但在严重肌病患者开始治疗后两年内，Ⅱ型纤维缺失仍很明显。结合预后对Ⅱ型纤维萎缩和缺失的发病机制及意义进行了讨论。
