Beerens A J F, Snow G B
Department of Otorhinolaryngology-Head and Neck Surgery, Vrije Universiteit Medisch Centrum, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Br J Surg. 2002 Jan;89(1):116-9. doi: 10.1046/j.0007-1323.2001.01982.x.
This was a prospective study of the treatment of Frey syndrome, also known as gustatory sweating, with botulinum toxin A.
Thirteen patients with a mean involved skin area of 53 (range 36-80) cm2, as assessed with the Minor starch-iodine test, were treated with 0.1 ml toxin (75 units/ml) injected intracutaneously into every 4 cm2 of involved skin. The mean total dose was 100 (range 67.5-150) units. Treatment results were assessed every 3 months with the Minor test. The Frey Questionnaire Card (FQC) was used for subjective assessment. The mean follow-up after primary treatment was 20 (range 9-24) months. Treatment was repeated if the symptoms recurred.
After 3 months 11 of the 13 patients showed a decrease of gustatory sweating of more than 90 per cent. All but one patient with a follow-up of 2 years suffered recurrent gustatory sweating. The mean recurrence-free period after primary treatment was 11 months and that after secondary treatment was 15 months. FQC score and objective assessment correlated well. Treatments were well tolerated, although two patients developed a temporary perioral muscle paresis.
Botulinum toxin A produces good results in the treatment of Frey syndrome. Repeated treatment improves on the results of primary treatment.
这是一项关于用A型肉毒杆菌毒素治疗弗雷综合征（又称味觉性出汗）的前瞻性研究。
13例患者，通过Minor淀粉碘试验评估，平均受累皮肤面积为53（范围36 - 80）cm²，将0.1 ml毒素（75单位/ml）皮内注射到每4 cm²受累皮肤中。平均总剂量为100（范围67.5 - 150）单位。每3个月用Minor试验评估治疗结果。使用弗雷问卷调查卡（FQC）进行主观评估。初次治疗后的平均随访时间为20（范围9 - 24）个月。如果症状复发则重复治疗。
3个月后，13例患者中有11例味觉性出汗减少超过90%。除1例随访2年的患者外，所有患者均出现味觉性出汗复发。初次治疗后的平均无复发期为11个月，二次治疗后的平均无复发期为15个月。FQC评分与客观评估相关性良好。治疗耐受性良好，尽管有2例患者出现了暂时性口周肌肉麻痹。
A型肉毒杆菌毒素治疗弗雷综合征效果良好。重复治疗可改善初次治疗的效果。
