普拉克索可改善亨廷顿舞蹈病韦斯特法尔变异型的神经和精神症状。
Pramipexole ameliorates neurologic and psychiatric symptoms in a Westphal variant of Huntington's disease.
作者信息
Bonelli Raphael M, Niederwieser Gerald, Diez Josef, Gruber Andreas, Költringer Peter
机构信息
Department of Neurology and Psychiatry, Hospital BHB Eggenberg, Graz, Austria.
出版信息
Clin Neuropharmacol. 2002 Jan-Feb;25(1):58-60. doi: 10.1097/00002826-200201000-00011.
Levodopa is recommended as a therapeutic approach for patients with the hypokinetic-rigid, Westphal variant of Huntington's disease, but no guidelines are available for the case of nonrespondence to levodopa. In this study, however, we report a 34-year-old woman with this rare variant who showed a clear-cut improvement in motor function and depressive symptoms after treatment with pramipexole, a new dopamine agonist.
左旋多巴被推荐作为患有运动不能-强直型韦斯特法尔变异型亨廷顿舞蹈病患者的一种治疗方法，但对于左旋多巴无反应的情况尚无指导方针。然而，在本研究中，我们报告了一名患有这种罕见变异型疾病的34岁女性，在用新型多巴胺激动剂普拉克索治疗后，其运动功能和抑郁症状有明显改善。
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