结核病中GroES N端肽的选择性T细胞识别
Selective T-cell recognition of the N-terminal peptide of GroES in tuberculosis.
作者信息
Chua-Intra Boosbun, Wilkinson Robert J, Ivanyi Juraj
机构信息
MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0NN, United Kingdom.
出版信息
Infect Immun. 2002 Mar;70(3):1645-7. doi: 10.1128/IAI.70.3.1645-1647.2002.
Abstract
Peptides derived from the whole sequence of mycobacterial GroES heat shock proteins were tested for the ability to induce the proliferation of blood mononuclear cells from tuberculosis patients and sensitized healthy subjects. The response to the N-terminal peptide (residues 1 to 16) was found to be more frequent and stronger in tuberculosis patients. This finding is exceptional, considering that recognition of all other GroES peptides by patients was either diminished or not different from that of controls.
摘要
对源自分枝杆菌GroES热休克蛋白全序列的肽段进行了测试，以检验其诱导结核病患者和致敏健康受试者血液单核细胞增殖的能力。结果发现，结核病患者对N端肽段（第1至16位氨基酸残基）的反应更为频繁且强烈。考虑到患者对所有其他GroES肽段的识别能力要么降低，要么与对照组无差异，这一发现很特殊。
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