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Smoking and acute myeloid leukemia: associations with morphology and karyotypic patterns and evaluation of dose-response relations.吸烟与急性髓系白血病：与形态学和核型模式的关联以及剂量反应关系评估
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Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow.吸烟与急性白血病风险：与骨髓形态学及细胞遗传学异常的关联
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细胞遗传学亚组中吸烟与急性髓系白血病风险

Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups.

作者信息

Moorman A V, Roman E, Cartwright R A, Morgan G J

机构信息

Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 30 Hyde Terrace, Leeds LS2 9LN, UK.

出版信息

Br J Cancer. 2002 Jan 7;86(1):60-2. doi: 10.1038/sj.bjc.6600010.

DOI:10.1038/sj.bjc.6600010
PMID:11857012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2746540/
Abstract

Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.

摘要

急性髓系白血病的细胞遗传学定义亚组具有不同的生物学特性、临床特征和预后。治疗相关白血病的证据表明，染色体异常也是暴露的标志物。我们的结果表明，吸烟相关的急性髓系白血病风险仅限于t(8;21)(q22;q22)亚组。这支持了急性髓系白血病不同细胞遗传学亚组具有不同病因的假说。