Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Cancer Epidemiol. 2013 Aug;37(4):410-6. doi: 10.1016/j.canep.2013.03.012. Epub 2013 May 2.
Cigarette smoking is an established risk factor for adult myeloid leukemia, particularly acute myeloid leukemia (AML), but less is known about the nature of this association and effects of smoking cessation on risk.
In a large population-based case-control study of myeloid leukemia that included 414 AML and 185 chronic myeloid leukemia (CML) cases and 692 controls ages 20-79 years, we evaluated risk associated with cigarette smoking and smoking cessation using unconditional logistic regression methods and cubic spline modeling.
AML and CML risk increased with increasing cigarette smoking intensity in men and women. A monotonic decrease in AML risk was observed with increasing time since quitting, whereas for CML, the risk reduction was more gradual. For both AML and CML, among long-term quitters (≥30 years), risk was comparable to non-smokers.
Our study confirms the increased risk of myeloid leukemia with cigarette smoking and provides encouraging evidence of risk attenuation following cessation.
吸烟是成人髓性白血病的既定危险因素，尤其是急性髓性白血病（AML），但对于这种关联的性质以及戒烟对风险的影响知之甚少。
在一项大型基于人群的髓性白血病病例对照研究中，包括 414 例 AML 和 185 例慢性髓性白血病（CML）病例和 692 名 20-79 岁的对照，我们使用非条件逻辑回归方法和三次样条建模评估了与吸烟和戒烟相关的风险。
在男性和女性中，AML 和 CML 的风险随着吸烟强度的增加而增加。随着戒烟时间的增加，AML 的风险呈单调下降趋势，而对于 CML，风险降低则更为渐进。对于 AML 和 CML 而言，在长期戒烟者（≥30 年）中，风险与不吸烟者相当。
我们的研究证实了吸烟与髓性白血病风险增加之间的关系，并提供了戒烟后风险降低的令人鼓舞的证据。
