Korsmeyer S J, Williams R C, Wilson I D, Strickland R G
N Engl J Med. 1975 Nov 27;293(22):1117-20. doi: 10.1056/NEJM197511272932203.
The prevalence of lymphocytotoxic antibody in inflammatory bowel disease is 40 per cent. Twenty-seven of 90 relatives of 23 probands with the disease (30 per cent) demonstrated lymphocytotoxic antibody, as contrasted with only three of 69 control family members (4 per cent) (P less than 0.0001). Decreased lymphocytotoxicity against lymphocytes from patients with inflammatory bowel disease as compared to normal donor lymphocytes previously demonstrated in the serum of probands was also observed in the serums from family members of the probands. Nineteen of the 48 household contacts of probands (40 per cent) were positive for antibody, whereas eight of 42 nonhousehold contacts (19 per cent) demonstrated it (P less than 0.05). Eight of 16 spouses (50 per cent) of probands showed antibody. The increased prevalence of lymphocytotoxic antibody in family members of probands and its occurrence mainly in household contacts (consanguineous and non-consanguineous) may indicate the exposure of probands and their family members to a common environmental agent.
炎症性肠病中淋巴细胞毒性抗体的患病率为40%。23名先证者的90名亲属中有27名（30%）显示出淋巴细胞毒性抗体，相比之下，69名对照家庭成员中只有3名（4%）显示出该抗体（P<0.0001）。在先证者血清中先前已证实，与正常供体淋巴细胞相比，针对炎症性肠病患者淋巴细胞的淋巴细胞毒性降低，在先证者家庭成员的血清中也观察到了这一现象。48名先证者的家庭接触者中有19名（40%）抗体呈阳性，而42名非家庭接触者中有8名（19%）显示有抗体（P<0.05）。16名先证者的配偶中有8名（50%）显示有抗体。先证者家庭成员中淋巴细胞毒性抗体患病率的增加及其主要发生在家庭接触者（有血缘关系和无血缘关系）中的情况，可能表明先证者及其家庭成员接触了共同的环境因素。
