感染恶性疟原虫或间日疟原虫的泰国成年人血清中的抗淋巴细胞毒性抗体。
Anti-lymphocytotoxic antibodies in sera of Thai adults infected with Plasmodium falciparum or Plasmodium vivax.
作者信息
Wells R A, Pavanand K, Zolyomi S, Permpanich B, Macdermott R P
出版信息
Clin Exp Immunol. 1980 Mar;39(3):663-7.
Abstract
Because of the potential for the elimination of lymphocytes through anti-lymphocytotoxic antibodies we examined individual sera of patients infected with falciparum or vivax malaria for the presence of antibodies against normal peripheral blood mononuclear cells. In assays done at 15 degrees C, 95% of the P. falciparum patients and 98% of the P. vivax patients showed evidence for antibody activity. Activity at 37 degrees C was significantly less than that at 15 degrees C. These studies suggest that infection with malaria induces anti-lymphocytotoxic antibodies which are predominantly cold-reactive. It is possible that this phenomenon plays a role in modulating the immune response of patients toward malaria.
摘要
由于抗淋巴细胞毒性抗体有清除淋巴细胞的可能性，我们检测了感染恶性疟或间日疟的患者个体血清中是否存在抗正常外周血单核细胞的抗体。在15℃进行的检测中，95%的恶性疟患者和98%的间日疟患者显示出抗体活性的证据。37℃时的活性明显低于15℃时的活性。这些研究表明，疟疾感染可诱导主要为冷反应性的抗淋巴细胞毒性抗体。这种现象可能在调节患者对疟疾的免疫反应中起作用。
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本文引用的文献
1
CYTOTOXIC ISO-ANTIBODIES AGAINST LEUCOCYTES.
Vox Sang. 1965 Mar-Apr;10:228-33. doi: 10.1111/j.1423-0410.1965.tb04345.x.
2
MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS.人血清细胞毒素的微滴分析法
Nature. 1964 Dec 5;204:998-1000. doi: 10.1038/204998b0.
3
Fetomaternal leukocyte incompatibility.母胎白细胞不相容性。
J Clin Invest. 1958 Dec;37(12):1756-63. doi: 10.1172/JCI103768.
4
Cytotoxins in disease. Autocytotoxins in lupus.疾病中的细胞毒素。狼疮中的自身细胞毒素。
N Engl J Med. 1970 Oct 1;283(14):724-8. doi: 10.1056/NEJM197010012831403.
5
Antibodies against cell membrane constituents in systemic lupus erythematosus and related diseases. I. Cytotoxic effect of serum from patients with systemic lupus erythematosus (SLE) for allogeneic and for autologous lymphocytes.系统性红斑狼疮及相关疾病中针对细胞膜成分的抗体。I. 系统性红斑狼疮（SLE）患者血清对同种异体和自体淋巴细胞的细胞毒性作用。
Clin Exp Immunol. 1971 Apr;8(4):543-50.
6
Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus.系统性红斑狼疮患者淋巴细胞毒素的相对T细胞特异性
Arthritis Rheum. 1973 May-Jun;16(3):369-75. doi: 10.1002/art.1780160312.
7
8
Malarial antibodies and autoantibodies to heart and other tissues in the immigrant and indigenous peoples of Uganda.乌干达移民和原住民体内的疟疾抗体以及针对心脏和其他组织的自身抗体。
Lancet. 1968 Jun 22;1(7556):1342-6. doi: 10.1016/s0140-6736(68)92037-0.
9
Immunology of malarial infection and its possible consequences.疟疾感染的免疫学及其可能的后果。
Br Med Bull. 1972 Jan;28(1):22-7. doi: 10.1093/oxfordjournals.bmb.a070886.
10
Lymphocytotoxic antibody in inflammatory bowel disease. A family study.炎症性肠病中的淋巴细胞毒性抗体。一项家族研究。
N Engl J Med. 1975 Nov 27;293(22):1117-20. doi: 10.1056/NEJM197511272932203.
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