DeHoratius R J, Messner R P
J Clin Invest. 1975 Jun;55(6):1254-8. doi: 10.1172/JCI108044.
57% of sera from 124 relatives of 28 patients with systemic lupus erythematosus (SLE) were found to have antibody directed against lymphocytes. The incidence in 60 members of 16 control families was 3%. Both consanguineous and nonconsanguineous relatives had the antibody in their sera. 68% of close household contacts of the SLE patients showed lymphocytotoxic antibody whereas only 23% of consanguineous relatives who had no household contact with the probands had this antibody. These data suggest that environmental factors may be important in the pathogenesis of SLE.
在28例系统性红斑狼疮(SLE)患者的124名亲属中,57%的血清被发现含有针对淋巴细胞的抗体。16个对照家庭的60名成员中,这一比例为3%。有血缘关系和无血缘关系的亲属血清中都有这种抗体。SLE患者68%的亲密家庭成员显示有淋巴细胞毒性抗体,而与先证者无家庭接触的有血缘关系的亲属中只有23%有这种抗体。这些数据表明,环境因素可能在SLE的发病机制中起重要作用。