DeHoratius R J, Pillarisetty R, Messner R P, Talal N
J Clin Invest. 1975 Nov;56(5):1149-54. doi: 10.1172/JCI108190.
Anti-RNA antibodies were found in 82% of 28 systemic lupus erythematosus (SLE) probands and in 16% of 124 of their family members. The incidence in 76 control family members was only 5%. In the SLE family members, the antibodies were found exclusively in 21% of the 94 close household contacts of the probands. The incidence of anti-native DNA (nDNA) antibodies was 68% for the SLE probands. The incidence of anti-nDNA antibodies in close household contacts of the probands was 6%, which was not significantly different from the 1% incidence found in control families. Lymphocytotoxic antibodies occurred in 57% of the SLE family members as a whole and in 68% of the close household contacts. In the SLE probands, lymphocytotoxic antibodies correlated with anti-single-stranded RNA (poly A) and anti-nDNA but not with anti-double-stranded RNA (poly A-poly U). On the other hand, lymphocytotoxic antibodies in the household contacts correlated with anti-double-stranded RNA (poly A-poly U) but not with anti-poly A or anti-nDNA. The anti-RNA antibodies were present in consanguineous household contacts but not in nonconsanguineous household contacts. These findings strengthen the hypothesis that both an environmental agent, possibly a virus, as well as the genetic response are important in the pathogenesis of SLE. Family members may therefore be a logical population in whom to search for specific antibodies to a viral agent.
在28例系统性红斑狼疮（SLE）先证者中，82%发现有抗RNA抗体，在其124名家庭成员中，16%发现有抗RNA抗体。76名对照家庭成员中的发生率仅为5%。在SLE家庭成员中，仅在先证者的94名密切家庭接触者中的21%发现有该抗体。SLE先证者中抗天然DNA（nDNA）抗体的发生率为68%。先证者密切家庭接触者中抗nDNA抗体的发生率为6%，与对照家庭中1%的发生率无显著差异。淋巴细胞毒性抗体在整个SLE家庭成员中的发生率为57%，在密切家庭接触者中的发生率为68%。在SLE先证者中，淋巴细胞毒性抗体与抗单链RNA（多聚A）和抗nDNA相关，但与抗双链RNA（多聚A-多聚U）无关。另一方面，家庭接触者中的淋巴细胞毒性抗体与抗双链RNA（多聚A-多聚U）相关，但与抗多聚A或抗nDNA无关。抗RNA抗体存在于有血缘关系的家庭接触者中，而不存在于无血缘关系的家庭接触者中。这些发现强化了这样一种假说，即一种环境因素，可能是一种病毒，以及遗传反应在SLE的发病机制中都很重要。因此，家庭成员可能是寻找针对病毒因子的特异性抗体的合理人群。
