van Montfrans J M, Bakker P S, Rekers-Mombarg L T, van Weissenbruch M M, Lambalk C B
Department of Obstetrics and Gynecology, Vrije Universiteit Medical Centre, The Netherlands.
Twin Res. 2001 Oct;4(5):318-20. doi: 10.1375/1369052012641.
Three recent studies reported that early depletion of the primordial follicle pool is likely to be an independent risk factor for Down's syndrome pregnancies. The size of the primordial follicle pool at birth is determined by oogenesis and by the rate of follicle atresia during the intra uterine period. Since intra uterine growth retardation was reported to be associated with a significantly reduced primordial follicle pool at birth, we investigated the possibility of a relation between low birth weight for gestational age and the risk of a Down's syndrome pregnancy. In a case control study, 95 women with a history of a Down's syndrome pregnancy and 85 controls provided information on their own birth weight and length of gestation. Birth weight standard deviation scores, indicating the difference in birth weight from a reference group, were significantly lower in Down's syndrome mothers than in controls. These findings illustrate that the risk of a Down's syndrome pregnancy is related to a low birth weight corrected for gestational age, possibly by a causal relation between intra uterine growth retardation and the size of the primordial follicle pool.
最近的三项研究报告称，原始卵泡池的早期耗竭可能是唐氏综合征妊娠的一个独立危险因素。出生时原始卵泡池的大小由卵子发生以及子宫内时期卵泡闭锁的速率决定。由于据报道子宫内生长迟缓与出生时原始卵泡池显著减少有关，我们研究了孕周低出生体重与唐氏综合征妊娠风险之间存在关联的可能性。在一项病例对照研究中，95名有唐氏综合征妊娠史的女性和85名对照者提供了她们自己的出生体重和孕周信息。唐氏综合征母亲的出生体重标准差分数（表明出生体重与参照组的差异）显著低于对照组。这些发现表明，唐氏综合征妊娠的风险与经孕周校正后的低出生体重有关，这可能是由于子宫内生长迟缓与原始卵泡池大小之间存在因果关系。
