Yerevanian B I, Koek R J, Ramdev S
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA.
J Affect Disord. 2001 Dec;67(1-3):167-73. doi: 10.1016/s0165-0327(01)00448-7.
Previous research has identified a high rate of anxiety disorders comorbidity in patients with a primary mood disorder diagnosis. Discrepancies between studies in the comorbidity prevalence of specific anxiety disorders in mood disorders, and of anxiety disorders comorbidity between unipolar depression and bipolar mood disorder are in part due to differences in sampling and diagnostic assessment methodology.
The authors reviewed the charts of 138 patients who received the SCID-P for DSM-III on enrollment in a Mood Disorders Clinic during the period 1982 through 1988. The comorbidity of specific DSM-III Anxiety Disorders with specific mood disorders was determined and comparatively examined using non-parametric statistics.
There was high overall comorbidity of anxiety disorders that did not differ between bipolar and unipolar subjects. There were no differences in the comorbidity of individual anxiety disorder diagnoses in the unipolar vs. bipolar groups. However, in unipolar patients with, compared to those without an additional diagnosis of dysthymia, there was greater overall anxiety disorders comorbidity, with a particularly high prevalence of generalized anxiety disorder.
The subgroup of patients with bipolar I disorder was relatively small (N=8).
Mood and anxiety disorders comorbidity is complex and presents a continuing challenge for both clinicians and researchers.
先前的研究已确定，在患有原发性心境障碍的患者中，焦虑症共病率较高。心境障碍中特定焦虑症共病患病率的研究之间，以及单相抑郁和双相心境障碍之间焦虑症共病情况的研究存在差异，部分原因在于抽样和诊断评估方法的不同。
作者回顾了1982年至1988年期间在一家心境障碍诊所登记时接受DSM-III的SCID-P检查的138例患者的病历。确定特定DSM-III焦虑症与特定心境障碍的共病情况，并使用非参数统计进行比较研究。
焦虑症总体共病率较高，双相和单相受试者之间无差异。单相组和双相组在个体焦虑症诊断的共病情况上无差异。然而，与未额外诊断为恶劣心境的单相患者相比，有恶劣心境额外诊断的单相患者总体焦虑症共病率更高，广泛性焦虑症的患病率尤其高。
双相I型障碍患者亚组相对较小（N = 8）。
心境障碍与焦虑症共病情况复杂，对临床医生和研究人员而言都是持续的挑战。
