Rihmer Z, Szádóczky E, Füredi J, Kiss K, Papp Z
National Institute for Psychiatry and Neurology, POB 1, Budapest 27, 1281 Hungary.
J Affect Disord. 2001 Dec;67(1-3):175-9. doi: 10.1016/s0165-0327(01)00309-3.
The aim of this study was to analyze the lifetime comorbidity between DSM-III-R anxiety disorders in separate subgroups of patients with major depression, bipolar II and bipolar I disorder in a community sample of a Hungarian population.
Randomly selected subjects (aged between 18 and 64 years, N=2953) were interviewed by the Diagnostic Interview Schedule (DIS) which generated DSM-III-R diagnoses.
The prevalence of generalized anxiety disorder, agoraphobia and simple phobia was the highest among bipolar II patients (20.8, 37.5 and 16.7%, respectively), social phobia was most prevalent in (nonbipolar) major depression (17.6%), while the rate of panic disorder was the same in the (nonbipolar) major depressive and bipolar II subgroups (12.4 and 12.5%, respectively). Bipolar I patients showed a relatively low rate of comorbidity.
The findings support previous results on the particularly high rate of lifetime comorbidity between anxiety disorders and unipolar major depression and particularly bipolar II illness.
Underestimation of the prevalence of bipolar II disorder by the diagnostic methodology used, resulting in a small number of bipolar II cases, lack of analysis of data by gender, no data on obsessive-compulsive disorder.
本研究旨在分析匈牙利人群社区样本中，重度抑郁症、双相II型障碍和双相I型障碍患者不同亚组中，DSM-III-R焦虑症的终生共病情况。
采用诊断性访谈表（DIS）对随机选取的受试者（年龄在18至64岁之间，N = 2953）进行访谈，以得出DSM-III-R诊断结果。
广泛性焦虑症、广场恐惧症和单纯恐惧症的患病率在双相II型患者中最高（分别为20.8%、37.5%和16.7%），社交恐惧症在（非双相）重度抑郁症中最为普遍（17.6%），而惊恐障碍在（非双相）重度抑郁和双相II型亚组中的发生率相同（分别为12.4%和12.5%）。双相I型患者的共病率相对较低。
这些发现支持了先前关于焦虑症与单相重度抑郁症尤其是双相II型疾病之间终生共病率特别高的结果。
所用诊断方法对双相II型障碍患病率的低估，导致双相II型病例数量较少，未按性别对数据进行分析，缺乏强迫症数据。
