Przewlocka B, Sarnek J, Szmigielski A, Niewiadomska A
Pol J Pharmacol Pharm. 1975 Sep-Oct;27(5):555-9.
In search for selective dopamine-beta-hydroxylase inhibitors, we studied the effect of dimethyl-, monocyclohexyl-, and dicyclohexyldithiocarbamic acids on the activity of this enzyme and on dopamine and noradrenaline levels in rat's brain. All the three derivatives inhibit the activity of dopamine-beta-hydroxylase in brain; in the tested doses, their effectiveness is similar. Moreover, all three compounds decrease noradrenaline level in brain. The tested derivatives differ from one another in their effect on dopamine level in brain. Dimethyl- and monocyclohexyl derivatives increase while dicyclohexyl derivative decreases the level of this amine.
为寻找选择性多巴胺-β-羟化酶抑制剂，我们研究了二甲基、单环己基和二环己基二硫代氨基甲酸对该酶活性以及大鼠脑内多巴胺和去甲肾上腺素水平的影响。这三种衍生物均抑制脑内多巴胺-β-羟化酶的活性；在测试剂量下，它们的效果相似。此外，这三种化合物均降低脑内去甲肾上腺素水平。所测试的衍生物对脑内多巴胺水平的影响各不相同。二甲基和单环己基衍生物会升高而二环己基衍生物会降低这种胺的水平。
